This article is based on a systematic review of gender-transformative HIV and violence prevention programs with heterosexually-active men in order to assess the efficacy of this programming. The authors find that gender-transformative interventions can increase protective sexual behaviors, prevent partner violence, modify inequitable attitudes, and reduce STI/HIV, though further trials are warranted, particularly in establishing STI/HIV impacts. The paper concludes with a discussion of the promises and limitations of gender-transformative work with men and recommendations for future research focused on HIV and/or violence prevention.